Future proofing Lovelace system development environment

Abstract. Software development methods and tools improve continuously to improve the development process. Modern software architecture has paved the way for microservice based architecture. The main point of microservice architecture is to split a system to small independent parts that can be deployed separately without affecting the other parts of the system. With microservices and tools, a system can achieve fault tolerance, scalability and faster release cycle with automation. The use of container technologies has increased and popularized with microservices, because containers simplify the deployment process. In this project, a modern development environment was introduced to help future development of a Virtual Learning Environment. The development environment included a public repository, containers, a container registry, container orchestration, server confguration and automated deployment. After successful implementation the simple mock up system was tested by smoke, load and spike testing methods. Overall the implementation and confguration was successful, however for implementing it for the Lovelace system in University of Oulu’s environment, some confguration and tool choices may need to be changed.Lovelace järjestelmän modernisointi tulevaisuuden kehitykseen. Tiivistelmä. Ohjelmistokehityksen tavat ja työkalut kehittyvät jatkuvasti helpottamaan, sekä parantamaan ohjelmiston kehitysprosesseja. Moderni ohjelmistoarkkitehtuuri on luonut tietä mikropalveluarkkitehtuurille, jonka päätarkoituksena on pilkkoa järjestelmä pieniin lähes itsenäisiin osiin, joita voidaan erikseen kehittää vaikuttamatta järjestelmän muihin osiin. Mikropalveluiden ja muiden työkalujen avulla järjestelmä saavuttaa vikasietoisuutta, skaalautuvuutta sekä nopeamman julkaisusyklin automaation ansiosta. Konttiteknologioiden käyttö on myös yleistynyt mikropalveluiden myötä, jotka helpottaa ohjelmiston toimittamista servereille. Tämän projektin aikana implementoitiin moderni kehitysympäristö helpottamaan jatkokehitystä Lovelace systeemille. Kehitysympäristö sisälsi julkisen säilön, kontin, kontti rekisterin, konttien orkesterointi työkalun, serveri confguroinnin ja automaattisen sijoituksen. Onnistuneen implementaation jälkeen, yksinkertainen järjestelmä testattiin savu, kuorma ja piikki testi metodeilla. Kokonaisuudessaan implementaatio ja confgurointi onnistuivat, mutta Lovelace implementaatio Oulun Yliopiston ympäristöön vaatii confgurointi muutoksia ja mahdollisesti muutamien työkalujen vaihtamista

The Magnitude of IMF By Influences the Magnetotail Response to Solar Wind Forcing

Under embargo until: 2022-04-21The dynamics of substorms are known to be dominated by the North-South (Bz) component of the Interplanetary Magnetic Field (IMF), which is the most important driver of the dayside reconnection. Even though the dawn-dusk (By) component is also known to play a role in substorm dynamics, its effects are not yet fully understood. In this paper we study how IMF By modulates the onset latitude, strength and occurrence frequency of substorms as well as the isotropic boundary (IB) latitude of energetic protons. We show that the substorm onset latitude and the IB latitude are about one degree lower for large magnitude By (>|By>|>3 nT) than for small By. In contrast, the substorm occurrence frequency is larger for small >|By>|. We suggest that the magnetotail is more stable during large >|By>|, requiring the magnetotail lobes (and hence the polar cap) to contain more flux to initiate a substorm compared to the situation when By is small.publishedVersio

Dependence of the global dayside reconnection rate on interplanetary magnetic field By and the earth’s dipole tilt

In the recent years, significant attention has been given to the combined effect of Interplanetary Magnetic Field (IMF) duskward component (By) and dipole tilt on the global magnetosphere-ionosphere system response. Numerous studies have pointed out that when the Earth’s magnetic dipole is tilted away from the Sun (negative dipole tilt during northern winter), and IMF has a positive By component, the effects on ionospheric currents, particle precipitation, ionospheric convection, and average size of the auroral oval, is significantly more enhanced, compared to when IMF By is negative. Furthermore, this IMF By polarity effect reverses when Earth’s dipole is tilted in the opposite direction. The underlying cause has remained unclear. Our analysis shows that substorms tend to be stronger during the same IMF By and dipole tilt polarity combination. Taken together with earlier results showing also more frequent substorms during the same conditions, our observations suggests that when IMF By and dipole tilt have opposite signs, there is a more efficient global dayside reconnection rate. We also show analysis of the occurrence frequency of periods of Steady Magnetospheric Convection, substorm onset latitude, and the isotropic boundary of proton precipitation, that are all consistent with our conclusion that the combination of IMF By and dipole tilt polarity affect the global dayside reconnection rate.publishedVersio

The use of unlicensed bone marrow-derived platelet lysate-expanded mesenchymal stromal cells in colitis : a pre-clinical study

Background: Mesenchymal stromal cells (MSCs) are a promising candidate for treatment of inflammatory disorders, but their efficacy in human inflammatory bowel diseases (IBDs) has been inconsistent. Comparing the results from various preclinical and clinical IBD studies is also challenging due to a large variation in study designs. Methods: In this comparative pre-clinical study, we compared two administration routes and investigated the safety and feasibility of both fresh and cryo-preserved platelet-lysate-expanded human bone marrow-derived MSCs without additional licensing in a dextran sodium sulfate (DSS) colitis mouse model both in the acute and regenerative phases of colitis. Body weight, macroscopic score for inflammation and colonic interleukin (IL)-1 beta and tumor necrosis factor (TNF)alpha concentrations were determined in both phases of colitis. Additionally, histopathology was assessed and Il-1 beta and Agtr1a messenger RNA (mRNA) levels and angiotensin-converting enzyme (ACE) protein levels were measured in the colon in the regenerative phase of colitis. Results: Intravenously administered MSCs exhibited modest anti-inflammatory capacity in the acute phase of colitis by reducing IL-1 beta protein levels in the inflamed colon. There were no clear improvements in mice treated with fresh or cryopreserved unlicensed MSCs according to weight monitoring results, histopathology and macroscopic score results. Pro-inflammatory ACE protein expression and shedding were reduced by cryopreserved MSCs in the colon. Conclusions: In conclusion, we observed a good safety profile for bone marrow-derived platelet lysate-expanded MSCs in a mouse pre-clinical colitis model, but the therapeutic effect of MSCs prepared without additional licensing (i.e. such as MSCs are administered in graft-versus-host disease) was modest in the chosen in vivo model system and limited to biochemical improvements in cytokines without a clear benefit in histopathology or body weight development.Peer reviewe